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Category of diseases Dermatological disease 6 (atopic predisposition) Neurological disease 1 (generalized brachioradial pruritus) Systemic disease 0 Mixed origin* 21 Unclear origin 2 *Co-factors of mixed origin Dermatological factors (n = 19) Atopic predisposition 15 Dry skin 2 Eczema 2 Systemic factors (n = 31) Sorbitol intolerance 12 Lactose intolerance 1 Helicobacter pylori 3 Anaemia (iron, vitamin B12 deficiency) 5 Diabetes mellitus 3 Hepatobiliary diseases 4 Nephrosclerosis 1 Drug-induced 2 Psychosomatic factors (n = 7) Psychosomatic cofactors 6 Depression 1

Intraepidermal Nerve Fibre Density is Decreased in Lesional and Inter-lesional Prurigo Nodularis and Reconstitutes on Healing of Lesions