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Hidradenitis suppurativa (HS) is an inflammatory skin disease characterized by painful nodules, abscesses and sinus tracts. The disease is located primarily in the apocrine gland-bearing skin, including the armpits and groins (1). Previous studies have shown that follicular occlusion is present in the majority of patients at an early stage of the disease (2–5); however, the driving mechanism behind this follicular occlusion is unknown. Recently, diminished periodic acid-Schiff (PAS) staining was found in the basement membrane zone (BMZ) of the sebofollicular junction (SFJ) at the folliculopilosebaceous units (FPSU) in perilesional HS skin (6). The authors suggest that the PAS-negative gaps represent primary defects in the BMZ, leading to fragility of the hair follicle. Diminished expression in one of the glycoproteins in the BMZ of the SFJ might explain these PAS-negative gaps; however, there was no staining for specific glycoproteins in this study. Therefore, we investigated the expression of the most important BMZ components, including type XVII collagen, type VII collagen, laminin-332, and integrin α6β4, of the follicular epidermis relative to the interfollicular epidermis in HS and compared the expression ratio with that of healthy controls.

Increased Expression of Integrin α6β4 in the Basement Membrane Zone Lining the Sebaceous Glands in Hidradenitis Suppurativa