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© 2015 The Authors. doi: 10.2340/00015555-1863 Journal Compilation © 2015 Acta Dermato-Venereologica. ISSN 0001-5555 Drug-induced hypersensitivity syndrome (DIHS), also known as drug reaction with eosinophilia and systemic symptoms (DRESS), is a rare and severe skin disease associated with systemic findings, such as fever, eosinophilia, lymphadenopathy, and internal organ involvement that typically develops 2 to 6 weeks after the drug intake, following a prolonged course with frequent flare-ups and relapses over weeks or even months after discontinuing the drug. This syndrome has been reported to be associated with the intake of anticonvulsants, sulfonamides and allopurinol (1). Several mechanisms are involved in its pathophysiology, such as drug toxicity, immunological imbalance and reactivation of the herpes virus family members. Recently, a certain type of human leucocyte antigen (HLA) was identified as a predisposing factor in DIHS/DRESS. Here, we describe a case of DIHS/ DRESS with remarkable eosinophilic pneumonia caused by zonisamide.

DIHS/DRESS with Remarkable Eosinophilic Pneumonia Caused by Zonisamide