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© 2014 The Authors. doi: 10.2340/00015555-1787 Journal Compilation © 2014 Acta Dermato-Venereologica. ISSN 0001-5555 Eccrine squamous syringometaplasia (ESS) is defined as the metaplasia of eccrine duct cuboid epithelial cells in squamous cells (1). It was first described by Cornil in 1865 in the periphery of what was then called adenoacan­ thoma, which is today known as acantholytic, adenoid or pseudoglandular squamous cell carcinoma. Although it has been described in some processes unrelated to the use of chemotherapy (squamous cell carcinoma, pseudoepi­ theliomatous hyperplasia, keratoachanthoma, etc.), most studies associate it with chemotherapy, both systemic and due to extravasation or intradermal injection of the chemotherapy (2, 3). Although the pathogenesis of ESS remains unclear, it seems that it represents a non-specific reaction to damaged eccrine ductal epithelium induced by different stimuli. Chemotherapy-induced ESS could be explained by damage to the eccrine ducts, by exces­ sive sweat gland production and/or drug concentration in this secretion. Moreover, other factors such as local irritation or friction may be implicated (1, 4). ESS does not require a specific treatment and it is not a prognosis factor; both depend on the underlying disease. It usually goes into remission spontaneously, but the use of topical or systemic corticosteroids may be useful if the lesions are itchy. The presence of ESS has rarely been described in patients receiving a haematopoietic stem­cell trans­ plantation (after conditioning with chemotherapy) who go on to develop a graft­versus­host disease (GVHD), its coexistence with acute GVHD being exceptional (4). We present a case with acute GVHD coexisting with ESS.

Coexistence of Eccrine Squamous Syringometaplasia and Graft-Versus-Host Disease in a Patient with Secondary Myelodysplastic Syndrome