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© 2014 The Authors. doi: 10.2340/00015555-1612 Journal Compilation © 2014 Acta Dermato-Venereologica. ISSN 0001-5555 Eosinophilic pustular folliculitis (EPF) is a rare dermatitis of unknown aetiology, characterized by recurrent clusters of pruritic, follicular, sterile papules and pustules on the face, trunk and upper extremities (1). EPF is often accompanied by peripheral blood eosinophilia, and a T-helper (Th) 2 cytokine-dominant condition has been postulated as a possible underlying mechanism (2). Macrophages are functionally polarized into M1 and M2 cells; M2 macrophages have important roles in the response to parasite infection, tissue remodelling, angiogenesis and tumourprogression, and have been shown to be involved in Th2 polarization (3). STAT6 participates in Th2 differentiation by enhancing expression of the master regulator of Th2 differentiation, GATA3 (4). STAT6 and GATA3, together with interleukin (IL)-2-mediated STAT5 activation, induce the secretion of copious amounts of IL-4, IL-5 and IL-13 by activated Th2 cells (5). In the present case, we investigated the immunohistochemical profiles of perifollicular and interstitial infiltrating cells, focusing on the profiles of immunosuppressive cells and Th2 signals.

Induction of CD163+ M2 Macrophages in the Lesional Skin of Eosinophilic Pustular Folliculitis