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© 2013 The Authors. doi: 10.2340/00015555-1444 Journal Compilation © 2013 Acta Dermato-Venereologica. ISSN 0001-5555 Plasma exchange is a therapeutic option in severe cases of pemphigus. Both centrifugal plasmapheresis and double filtration plasmapheresis (DFPP) are available, but the latter, newer, procedure currently prevails because of its safety advantage (1, 2). In DFPP, immunoglobulins (Igs) are selectively removed, while minimizing the loss of albumin (3). In several studies, the removal rates (RRs) of anti-desmoglein (Dsg) 1 and Dsg3 autoantibodies have been estimated by using serum antibody titres immediately before and after plasmapheresis (3). This simple estimation is designated RR1 in the present study. Given the data for anti-Dsg titres and Ig amounts in the exchanged effluents, however, we can calculate the corrected or compensated RR, named RR2 in this study, which reflects the elimination efficacy of antibodies more accurately than RR1. RR2 of pemphigus autoantibodies has been reported only in centrifugal plasmapheresis (4), but not in DFPP. This study examined RR2 of anti-Dsg1 autoantibody with reference to total immunoglobulins (Igs) in 4 cycles of DFPP performed in 2 patients with pemphigus foliaceus (PF).

Clearance Efficacy of Autoantibodies in Double Filtration Plasmapheresis for Pemphigus Foliaceus