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© 2013 The Authors. doi: 10.2340/00015555-1390 Journal Compilation © 2013 Acta Dermato-Venereologica. ISSN 0001-5555 Hailey-Hailey disease (HHD) is an autosomal dominant inherited disorder characterized by suprabasal acantholysis of the epidermis. In patients with HHD, itch and pain are common, with recurrent erosive erythema predominantly on the flexural areas, and quality of life may be reduced (1, 2). Treatment recommendations include the avoidance of skin friction and retention of a dry environment in the flexural area. Topical cortico­ steroids are usually effective only with concomitant use of antibacterial and/or antifungal agents. In some cases, however, those topical treatments may have no beneficial effect. Several new therapeutic approaches have been reported to be effective, although they lack an adequate evidence base obtained from controlled trials (3–7). While ultraviolet (UV) light may induce acantholysis in the epidermis in patients with HHD, previous investigators have been successful with the use of phototherapy (8). However, a major drawback of this treatment is the anatomical difficulty of full irradiation in the flexural area. Thus, a novel approach using Excimer irradiation, has been tested.

Successful Therapeutic Use of Targeted Narrow-band Ultraviolet B Therapy for Refractory Hailey-Hailey Disease