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Mucous membrane pemphigoid (MMP) is an often diffi-cult-to-treat autoimmune bullous disease characterized by circulating auto-antibodies targeting the dermo-epidermal junctional zone (1–3). Due to limited disease control and/or severe adverse reactions to glucocorticoids and conventional immunosuppressants, alternative treatment options are frequently needed. We describe here the first successful therapy of refractory MMP with rituximab, a humanized anti-CD20 monoclonal antibody depleting B-lymphocytes (4, 5), that resulted in a complete and persisting remission.CASE REPORT

Successful Treatment of Mucous Membrane Pemphigoid with the Anti-CD-20 Antibody Rituximab