English (United Kingdom)

https://curated-unify.zendy.io/wp-json/zendy-region/v1/featured_content/oa?rat=en

https://curated-unify.zendy.io/wp-json/zendy-region/v1/highlighted_journal/

Global: Zendy Plus annual

Presents the access of premium content as premium feature

Premium Content

Presents the keyphrase highlighting as premium feature

Keyphrase Highlighting

Presents the summarisation as premium feature

Summarisation

Insights

Presents the pdf analysis as premium feature

PDF Analysis

Presents the zaia usage as premium feature

ZAIA

Global: Zendy Tools annual

Global: Zendy Free Plan

Global: Zendy Tools monthly

Global: Zendy Plus monthly

A 49-year-old man presented in 1998 with a 10-year history of multiple recalcitrant viral warts on his hands, groin and scrotal area. He also had an SCC in situ excised from his scrotum in 1995 and from his left palm in 1998. There was no other history of note. ICL was considered. Immunological tests showed a low CD4+ count of 420 cells/mm3 (normal 700–1000 cells/mm3) equal to less than 16% of total CD count and a slightly raised CD8+ count of 930 cells/mm3 (normal 500–900 cells/mm3). Tests for human immunodeficiency virus (HIV)1 and HIV2 as well as human T-cell lymphotropic virus (HTLV)1 and HTLV2 were negative. Serum immunoglobulins were normal. The diagnosis of ICL was established. Since 2000 he has developed 3 further SCC in situ on the scrotum and left palm (Fig. 1), 3 condylomata accuminata on the suprapubic area, groin and thigh (Fig. 2), multiple intra-epithelial carcinomas on the scrotum, suprapubic area, lower abdomen and waistline and multiple viral warts on the hands and fingers (Fig. 1). His therapy so far has consisted of: imiquimod for the lesions on the scrotum, with very good response; fluoruracil cream and photodynamic therapy to a lesion on the thigh, with moderate response; multiple cryotherapy for viral warts on the hands and for extensive Bowen’s disease on the lower abdomen and suprapubic area; and multiple excisions, curettage and cautery. He is currently on oral acitretin 50 mg daily with moderate response. His most recent CD4+ count is 16% of the total CD count. The CD8+ count is still mildly raised.

Idiopathic CD4+ T-cell Lymphocytopaenia Associated with Recalcitrant Viral Warts and Squamous Malignancy