Open AccessElevated Serum IP-10 Levels Observed in Type 1 Diabetes
Author(s) -
Akira Shimada,
Jiro Morimoto,
Keiichi Kodama,
Ryuji Suzuki,
Yoichi Oikawa,
Osamu Funae,
Akira Kasuga,
Takao Saruta,
Shosaku Narumi
Publication year - 2001
Publication title -
diabetes care
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 6.636
H-Index - 363
eISSN - 1935-5548
pISSN - 0149-5992
DOI - 10.2337/diacare.24.3.510
Subject(s) - medicine , diabetes mellitus , type 2 diabetes , type 1 diabetes , endocrinology
Although most patients with type 1 diabetes are considered to have T-cell-mediated autoimmune disease, a method of measuring of pancreatic beta-cell-specific T-cell function in cases of type 1 diabetes has yet to be established. Here, we focused on interferon-inducible protein-10 (IP-10), a chemokine that promotes the migration of activated T-helper 1 (Th1) cells and measured serum IP-10 levels in patients with human type 1 diabetes, which is regarded as a Th1-mediated disease.
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