Open AccessDemonstration of Glucagon in the Stomach of Human Fetuses
Author(s) -
Mariella Ravazzola,
Roger H. Unger,
Lelio Orci
Publication year - 1981
Publication title -
diabetes
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 3.219
H-Index - 330
eISSN - 1939-327X
pISSN - 0012-1797
DOI - 10.2337/diab.30.10.879
Subject(s) - ultrastructure , fetus , glucagon , stomach , antiserum , population , biology , immunocytochemistry , human stomach , electron microscope , pathology , pancreas , antibody , endocrinology , medicine , anatomy , biochemistry , pregnancy , hormone , immunology , physics , environmental health , optics , genetics
Electron microscopy using antiglucagon or antiglicentin antisera and the protein A-gold (pAg) technique revealed a population of immunoreactive cells in the gastric mucosa of human fetuses. The secretory granules of these cells showed the same ultrastructural characteristics and the same labeling pattern as pancreatic alpha-granules. These data demonstrate that the stomach of human fetuses contains cells with secretory granules indistinguishable by morphologic and immunocytochemical criteria from the pancreatic A-cells.
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