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We appreciate the comments of Drs. Jialal and Devaraj (1) on our article (2). Our study was run concomitantly with the study reported by Joslin investigators (3) and reached similar conclusions concerning the predictive value of soluble tumor necrosis factor (TNF) receptors in nephropathy progression. We mentioned their results in our discussion. We did not mention the possible role of increased Toll-like receptor (TLR) activity in triggering the TNF pathway as other alternative explanations could better explain our findings. We previously published data showing that oxidized LDL immune complexes (oxLDL-ICs) are associated with and predict the development of proteinuria (4) and that oxLDL-ICs are much stronger activators of the TNF pathway than oxLDL, which activates innate immunity through the interaction with TLR-4 (5).The concern over the relationship between soluble vascular cell adhesion …

diabetes care

Response to Comment on Lopes-Virella et al. Baseline Markers of Inflammation Are Associated With Progression to Macroalbuminuria in Type 1 Diabetic Subjects. Diabetes Care 2013;36:2317–2323