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Ingestion of a high-fructose meal increases blood uric acid (UA) concentration in healthy subjects (1). Furthermore, high-fructose intake over several days is associated with increased fasting UA concentration (1). These effects are generally attributed to an increased UA production, as observed after intravenous fructose administration (2). It has not been assessed, however, whether UA also increases when fructose is administered as several small drinks instead of one single large load or whether a high-fructose diet (HFrD) impairs renal UA clearance (UAC) or fractional excretion (UAFE) as observed in rats (3). We therefore measured blood and urine UA and creatinine concentrations (RX Monza; Randox Laboratories, London, U.K.) and calculated UAC and UAFE in 16 healthy male subjects (mean ± SD age 22.6 ± 2.9, weight 69.7 ± 6.9 kg, BMI 22.1 ± 1.8 kg/m2, mean fat-free mass [FFM] 57.8 ± 5.4 kg) over a 9-h period during which they drank lemon-flavored …

Fructose-Induced Hyperuricemia Is Associated With a Decreased Renal Uric Acid Excretion in Humans