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Women exhibit exaggerated renal hemodynamic responses to hyperglycemia, which may promote kidney disease progression. Our aim was to determine if increased nitric oxide generation by l-arginine infusion would reverse this deleterious response to clamped hyperglycemia in women with type 1 diabetes mellitus.

Sex Differences in Renal Responses to Hyperglycemia, l-Arginine, and l-NMMA in Humans With Uncomplicated Type 1 Diabetes