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The G6PC2 gene encoding islet-specific glucose-6-phosphatase related protein (IGRP) has a common promoter variant, rs573225 (-231G/A), located within a Foxa binding site. We tested the cis-regulatory effects of rs573225 on promoter activity and its association with insulin response to oral glucose.

diabetes

A Single-Nucleotide Polymorphism in a Methylatable Foxa2 Binding Site of the <i>G6PC2</i> Promoter Is Associated With Insulin Secretion In Vivo and Increased Promoter Activity In Vitro

A Single-Nucleotide Polymorphism in a Methylatable Foxa2 Binding Site of the G6PC2 Promoter Is Associated With Insulin Secretion In Vivo and Increased Promoter Activity In Vitro