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NOD mice model human type 1 diabetes and are used to investigate tolerance induction protocols for islet transplantation in a setting of autoimmunity. However, costimulation blockade-based tolerance protocols have failed in prolonging islet allograft survival in NOD mice.

IddLoci Synergize to Prolong Islet Allograft Survival Induced by Costimulation Blockade in NOD Mice