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Efficacy of single intracisternal bolus injection of tissue plasminogen activator (t-PA) for cerebral vasospasm were studied using double hemorrhage canine model. Each doses of 250 ,ug, 25 μg of t-PA, and 25 [ig of t-PA with 50 CU of plasminogen were injected into cisterna magna 3hours after the second hemorrhage on Day 2. In the treated dogs with t-PA, clot lysis were facilitated, and significant inhibition of angiographical vasospasm were observed. Hb and FDP in cerebrospinal fluid decreased earlier in treated group. Intracisternal bolus injection of t-PA is highly efficacious for preventing cerebral vasospasm following subarachnoid hemorrhage (SAH).

Effect of Single Intracisternal Bolus Injection of Tissue Plasminogen Activator on Experimental Vasospasm after Subarachnoid Hemorrhage