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Our previous study indicated that He-irradiated collagen grafts with a fluence of 1× 10 ions/cm have excellent blood compatible properties. Also, the collagen grafts demonstrated a high antithrombogenicity and graft patency. 150 keV-He irradiated collagen with a fluence of 1× 10 ions/cm simultaneously has the 2 properties of antithrombogenicity and cell attachment. In vitro platelet adhesion and plasma protein adsorption were evaluated to investigate the mechanisms of antithrombogenicity of these surfaces. Antithrombogenicity of the He-irradiated collagen was caused by the reduction of the plasma protein adsorption such as the von Willebrand factor by ion beam irradiation. He-irradiated collagen surfaces will be useful for the substrates of small-diameter vascular grafts.

Control of Platelet Adhesion and Cell Attachment to He+ Ion Irradiated Collagen for the Development of Small Diameter Vascular Graft Material