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The swimming behavior, external feature of bodies, and the condition of internal organs of two specimens of goldfish (so-called Wakin) under the polycystic kidney disease were ob-served macroscopically. The kidnies, livers, pituitaries, pharyngeal and heterotopic thyroid follicles, adrenal cortical tissues and ovaries of them were also examined histologically. The results obtained are as follows: 1. The wall of trunk of the fish swells markedly like a ball; one of the two fish had been swimming or floating upside down. The scales extended rose in consequence of the dropsy. The digestive organs and ovary are pushed aside ventrally as a result of striking expansion of the kidney. 2. Some masses of cyanophiles crowded in the islands were recognized in the meso-adenohypophysis. In a specimen which has abundant AF-, and CH-positive granules in its preopticonuclei a few amount of the storage of neurosecretory materials was encountered in then eurohypophysis. The follicles of pharyngeal thyroid gland showed remarkable hypofunc-tioning figure, and the same was detected in the heterotopic thyroid follicles scattered in the head kidney. The adrenal cortical tissue, however, appeared rather normal state. 3. The marked decrease in the volume of ovary was found. The development of ovarian eggs scaresely reached the stage of yolk vesicle formation, although many of pre-ovulation eggs are in the process of formation of corpora lutea. A marked hyperplasia of the granulosa cells is produced around the theca externa of some of the atretic eggs, and indicated like an early phase of epithelioma (granulosa cell tumor). On the other hand, small quantity of cells retained in their normal situation ingest the yolk as a matter of course. Noticeably, any ovulation scars (or empty follicles) could not encountered in the ovary. 4. The liver cells showed the figures like those of the so-called ghost cells; it is difficult to stain the cytoplasm with dyes, and there are no chromatin substances besides one nucleo-lus. The kidney consisted of many cysts in various sizes, each of which is filled with serous fluid. Between each cystic wall remarkable hyperplasia of connective tissue is detected, al-though some masses of nephrons in normal appearance are retained here and there. 5. Possible significance of the histological figures of endocrine glands observed was dis-cussed.

NOTES ON THE POLYCYSTIC KIDNEY DISEASE IN THE GOLDFISH, WITH DESCRIPTION OF SOME OF THE ENDOCRINE GLANDS