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(human EGF), was later extracted from human urine2). EGF is a potent mitogen for various types of mammalian cells, and its mode of action has been studied extensively and reviewed in detail3,4). In mouse submandibular gland, the synthesis of EGF is largely stimulated by androgen, and thus the concentration in the gland is exceedingly higher in the male than in the female5). In addition, it has been shown that thyroid hormone and

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Effects of hypophysectomy and subsequent administrations of testosterone, triiodothyronine, and growth hormone on epidermal growth factor concentration in rat submandibular gland.