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To evaluate the safety of dentifrice and mouthwash solution, we investigated the influence of sodium lauryl sulfate (SLS) and glycerine contained in most of the commercially available dentifrice and mouthwash solution on various cells. The effect of various concentrations of SLS on the morphology of human keratinocytes was observed. As a result, immediately after applying 0.01% SLS, a decrease in the size of the cells was observed, then most of the cells showed lyses and disappeared in one minute. In cases of applying 0.001% SLS, a decrease in the size of the cells started three minutes after application ; however, the rate of the decrease was small. After applying various concentrations of SLS to human erythrocytes, the morphology of the erythrocytes changed from the normal discocytes to the echinocytes depending on the concentration of SLS. In cases of applying more than 0.004% SLS, the erythrocytes showed hemolyses one minute efter application. After applying various concentrations of SLS to normal human aortic endothelial cells (HAEC) , in cases of applying more than 0.0022% SLS, the cells showed changes one minute after application, then most of the cells showed lyses and disappeared in five minutes. After applying glycerine to the various cells, the damage to the cells by glycerin was not great under the conditions of low concentrations and short periods of application. Observation of the actionsites of SLS on the human erythrocytes suggested the involvement of membrane proteins. From these findings, it is necessary to be careful with the use of SLS and glycerine, especially because even a minute amount of SLS caused damage to the various cells. J. Jpn. Soc. Periodontol., 43: 1-12, 2001

Influence of Sodium Lauryl Sulfate and Glycerine on the Various Cells.