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Four kinds of 41K protein fractions were prepared from a cell envelope fraction of Fusobacterium nucleatum ATCC 10953 by treatment with lithium dobecyl sulfate or sodium N-lauroyl sarcosinate. These protein fractions had porin activity, namely the ability to form hydrophilic diffusion pores in artificial liposome membrane containing them. They were also revealed to exhibit the following immunobiological activities: 1. Strong B cell mitogenicity and polyclonal B cell activation (PBA) on murine splenocytes. 2. Stimulating effects on peritoneal macrophages from a guinea pig to increase incorporation of glucosamine and release of superoxide anion and to decrease uptake of thymidine. 3. Migration enhancing activity on human blood monocytes under the conditions that the LPS had no effects. 4. Immunoadjuvant activity to increase antibody producing cells against sheep red blood cells (SRBC) in spleen of mice, after intraperitoneal injection of them with SRBC. Results of chemical analysis revealed that contamination of peptidoglycan in porin fractions was detected, while the presence of LPS were not neglected. Nevertheless, the mitogenic and PBA activities of the porin fractions on murine splenocytes were proved not to derive from LPS. These effects were detected in LPS non-responder C 3H/HeJ mice and were not depressed by addition of polymyxin B that inhibits the effect of LPS.

Immunobiological activity of 41K protein (porin) derived from the cell envelope of Fusobacterium nucleatum.