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Pure magnesium and its alloys are biocompatible and biodegradable. In cardiovascular surgery, they have been experimentally applied for short-term use as tiny devices. Many studies have been performed on rats and mice using X-ray imaging and CT scanning. However, these small animals have a low radiation resistance and the lethal exposure dosage is small. In orthopedic surgery, fracture xation using magnesium materials has high potential applicability. Although long-term stable xation is required, few long-term animal studies have been performed. Therefore, many unclear issues still remain. Accordingly a long-term animal study was performed on Dutch rabbits to investigate the biodegradation of pure magnesium. Specimens implanted into rabbit femurs showed a volume reduction of 40–50% at 52 weeks. Bone resorption was observed in cancellous bone, and new bone formation and direct contact were partially observed. No magnesium hydroxide was observed in the surrounding area. [doi:10.2320/matertrans.MI201517]

Biodegradation of Pure Magnesium and Bone Tissue Reaction in Rabbit Femur 1 Year Results of 3D Micro-CT Monitoring and Histological Observation