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This study deals with the effect of Eimeria nieschulzi infection on the host immune re- sponse to Trichinella spiralis. Six male Sprague-Dawley rats were inoculated with 10' and six with 10'; sporulated E. nieschulzi oocysts. On days 2, 8, and 16 postinoculation (PI), two rats from each infected group, and their paired uninfected controls, were killed and mucosal scrapings from their small intestines were assayed for peroxidase activity. Peroxidase levels were higher than correspond- ing control values on days 2 and 16 PI and significantly lower than the controls on day 8 PI. These data led us to initiate the present study because infection by T. spiralis in rats is known to cause an elevated gut peroxidase level which, in turn, is thought to contribute to worm expulsion. Twenty- eight male rats were then immunized by administration of 7.5 X 103 freshly isolated T. spiralis larvae. Thirty-two days after immunization 16 rats were inoculated with 5 X 105 sporulated oocysts of E. nieschulzi. The other 12 rats were retained as immlune controls. Each of the 28 rats was challenged with 7.5 X 103 T. spiralis larvae between 2 and 10 days postinoculation with E. nieschulzi. Two or three coccidia-infected rats and two immune controls were killed at 2 and 5 days postchallenge with T. spiralis, and the worms in each third of the small intestine were recovered and counted. In every instance, rats that had concurrent coccidia infections harbored at least 4 times more T. spiralis than did immune, coccidia-free controls. Distribution of T. spiralis through the small bowel was not al- tered by infection with E. nieschulzi, despite the fact that the coccidian significantly suppressed worm rejection. Information in the literature showed that rodent hosts infected with such nematodes as Nippostrongylus brasiliensis and Ancylostoma

Suppressed Rejection of Trichinella spiralis in Immunized Rats Concurrently Infected with Eimeria nieschulzi