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The FMRFamide-related peptides F1 and F2, originally isolated from lobster pericardial organs, have been shown to exert cardioexcitatory effects on isolated or semi-isolated crustacean hearts. The present study sought to determine the in vivo effects of F1 and F2 on cardiac and circulatory performance of Cancer magister using a pulsed-Doppler technique. In general the effects of F1 and F2 were similar; however, F1 was more potent and its effects were of longer duration than those exerted by F2. Infusion of either F1 or F2 caused a decrease in heart rate and subsequent periods of acardia. These decreases in rate occurred concurrently with a short-term increase in stroke volume of the heart, followed by a longer-term decrease in stroke volume. Hemolymph flow rates through the anterior aorta, anterolateral arteries, sternal artery, and posterior aorta also showed the same trend, with an initial short-term increase in flow rate followed by a longer-term decrease with periods of ischemia. Hemolymph flow through the paired hepatic arteries simply decreased, but recovery to pretreatment levels was faster than in the other arterial systems. Threshold for these responses occurred at circulating concentrations between 10(-9) mol.l-1 and 10(-8) mol.l-1 for F1 and somewhat higher, between 10(-8) mol.l-1 and 10(-7) mol.l-1, for F2.

The FMRFamide-Related Peptides F1 and F2 Alter Hemolymph Distribution and Cardiac Output in the Crab Cancer magister