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The hepatitis C virus (HCV) contains seven genotypes heterogeneously distributed around the world. HCV displays a high genetic diversity relevant to epidemiology, transmission, and clinical management. To explore the genetic variation of HCV in a local Thai population, we investigated the restriction fragment length polymorphism (RFLP) pattern of the core gene in 31 samples of HCV genotype 3a found in blood donors. The polymorphisms of these HCVs were clustered into five RFLP patterns (IV). Fifteen samples (48%) clustered as the RFLP pattern I and ten samples (32%) as pattern III profiles which have been previously reported. In addition, there were four samples (13%) manifest as pattern II, one sample (3%) as pattern IV, and one sample (3%) as pattern V. This study provides pointers to the molecular epidemiology of HCV genotype 3a distributed in Thailand.

The hepatitis C virus core gene yields restriction fragments of variable length and polymorphism