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The protective effect of anthocyanins extracted from black rice against learning and memory impairment was investigated in mice. In a Morris water maze test, mice with transient cerebral ischaemia required a longer time to find the hidden platform than the sham-operated controls. Daily treatment of cerebral-ischaemia mice with black rice extracts (125, 250, and 500 mg/kg body weight) significantly decreased the escape latency and increased the percentage crossing the former platform quadrant in the probe trial. Furthermore, less lipid oxidation was found in the brains of cerebral-ischaemia mice fed with black rice extract. Overall, black rice extract supplementation could be advantageous in the protection against oxidative stress and oxidative damage in the brains of cerebral-ischaemia mice.

Learning and memory enhancing effects of anthocyanin in black rice extract on cerebral ischaemia in mice