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Three simple, rapid, reliable, and cost-effective methods based on titrimetry and spectrophotometry in non-aq. medium are described for the detn. of ranitidine in pharmaceuticals.  In titrimetry, the drug dissolved in glacial acetic acid was titrated with acetous perchloric acid with visual and potentiometric end point detection, crystal violet being used as indicator for visual titrn.  Spectrophotometry involved adding different amts. of the drug to a fixed amt. of perchloric acid-crystal violet mixt. followed by measurement of absorbance at 570 nm.  The absorbance was found to increase linearly with the concn. of the drug and formed the basis for quantification.  The titrimetric methods are applicable over 1-15 mg range of ranitidine, and in spectrophotometry, calibration graph was linear from 10 to 70 Î¼g ml-1.  The apparent molar absorptivity is calcd. to be 2.2 Ã 103 l mol-1 cm-1 and the calcd. Sandell sensitivity is 161.7 ng cm-2.  The limits of detection and quantification are found to be 1.07 and 3.58 Î¼g ml-1, resp.  The procedures were used to det. ranitidine in pharmaceutical products and the results were found to be in good agreement with those obtained by the ref. method.  Assocd. pharmaceutical materials did not interfere.  The accuracy and reliability of the methods were further ascertained by recovery studies via std.-addn. technique with percent recoveries in the range 96.3 to 102.5 %. [on SciFinder(R)

Determination of drug content of pharmaceuticals containing ranitidine by titrimetry and spectrophotometry in non-aqueous medium.