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Biological agents targeting a specific molecule have extraordinarily fine specificityand powerful functional capabilities. By the introduction of biological therapy, management ofrheumatoid arthritis has undergone a revolution and a paradigm shift. In this review, I willsummarize the role in the pathogenesis of rheumatoid arthritis of the molecules targeted bybiological agents. Providing evidence obtained in clinical trials and investigator-initiatedclinical studies in Japan, the effectiveness and safety of biological therapy in rheumatoidarthritis are discussed. Finally, studies aiming at a personalized strategy with biologicalagents are listed and the future perspectives toward tailor-made medicine in the field ofrheumatology are discussed.

Revolutionary Change in Rheumatoid Arthritis Managementwith Biological Therapy