English (United Kingdom)

https://curated-unify.zendy.io/wp-json/zendy-region/v1/featured_content/oa?rat=en

https://curated-unify.zendy.io/wp-json/zendy-region/v1/highlighted_journal/

Global: Zendy Plus annual

Presents the access of premium content as premium feature

Premium Content

Presents the keyphrase highlighting as premium feature

Keyphrase Highlighting

Presents the summarisation as premium feature

Summarisation

Insights

Presents the pdf analysis as premium feature

PDF Analysis

Presents the zaia usage as premium feature

ZAIA

Global: Zendy Plus monthly

Global: Zendy Tools annual

Global: Zendy Tools monthly

Global: Zendy Free Plan

In the previous paper, it was shown that interleukin 2 (IL-2) enhanced NK cell activity against renal carcinoma cell lines and fresh solid tumor cells of renal cell carcinoma (RCC) which are not susceptible to NK cells, and that IL-2 in-duced a higher cytotoxicity than interferon γ (IFN-γ).The present study was carried out to examine the mechanism of the en-hanced cytotoxicity of IL-2 and IFN-γ in vitro, and to investigate the effects of NK cell activity when peripheral blood lymphocytes (PBL) are simultaneously treated with these lymphokines.To test the proliferative response of PBL, 3H-TdR incorporation was deter-mined. Effector lymphocytes, that proliferated in the presence of IL-2 but not in IFN-γ, required DNA synthesis for the induction. These lymphocytes also significantly increased phenotype in Leu 11+ cells (p<0.001).IFN-γ at a concentration of 80IU/ml, when added to PBL incubated with IL-2 (100 IU/ml), increases the percentage of IL-2 receptors (IL-2R) and induced a greater enhancement in NK cells activity than that incubated with IL-2 alone.This study concluded that the combination IL-2 and IFN-γ treatment, when given to patients with RCC, might produce synergistic effects of cytotoxicity through the induction of IL-2R.

Interleukin 2 induced cytotoxicity on renal cell carcinoma. 2 Synergistic effects of interleukin 2 and interferon gamma.