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Analysis of basal body temperature patterns (BBT) after continuous treatment with sex-steroids reveals that an extremely high percentage of subjects experience a delayed re-establishment of ovulation in the post treat-ment cycles, whereas the delayed re-appearance of ovulation is also observed with a high percentage in the recovery process of hypothalamic, pituitary and ovarian functions after abortion or premature delivery. It is, therefore, suggested that these endocrine functions are affected to a certain extent by the use of sex-steroids or by the gestation.On BBT1. In the first cycle after the termination of sex-steroidal treatment, 76% of the 6-cycle (treatment) group, 92.3% of the 12-cycle group and 87.5% of the 18-20-cycle group showed a prolonged menstrual cycle.2. Noticeable characteristics in (1.) above, were a lengthened low phase and a shortened high phase. This low phase correlated with treated durations.3. The onset date of first menstruation in the post gestational period was delayed in the premature delivery group, and the noticeable charac-teristics were a lengthened low phase and a shortened high phase. This low phase correlated with gestational durations before abortion or premature delivery.On LH-RH test1. LH response to LH-RH was detected from 2nd week (counting from 1st day of withdrawal bleeding after treatment) in 6- and 12-cycle groups, and from 3rd week in the 18-20-cycle group.2. FSH response to LH-RH in 12- and 18-20-cycle groups showed a remarkably high level from 1st week, whereas its response in the 6-cycle group registered a slightly high level.3. In the 6-cycle group, the larger the amount administered, the longer delayed the recovery in LH response to LH-RH and the more remarkable the increase of FSH response.4. The recovery in LH response to LH-RH in the premature delivery group was delayed compared with that in the abortion groups, and its response was noticed in the 4th week after premature delivery.5. FSH response to LH-RH weekly exceeded a higher level in the pre-mature delivery group than that in the abortion groups. As ovulation ap-proached, FSH recovered a normal preovulatory stage level.

keio journal of medicine

Study on re-establishment of ovulation after termination of sex-steroidal treatment. Compared with re-appearance of ovulation after abortion and premature delivery.