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Many of otorhinolaryngologists are very apt to encounter a development of shock after an injection of local anesthetic drugs in the palatopharyngeal region during surgery. Suzuki et al.1,2 reported statistics of the surgical shock in the otorhino laryngological procedures and called an attention to the fact that fifty-three per cent of all surgical shocks was followed by an injection of local anesthetics. In 1963 Suzuki and his collaborators had also reported an extensive study of Reilly's phenomenon, sydrome d'irritation, connecting with the otorhinolaryn gological field and had stressed that a peculiarity of the region of head and neck which contained many great vessels and nerves was responsible to the development of shock after an excessive irritation was added to the autonomic nervous system in this paticular region. In this study they had also found that the shock could be prevented by parenteral administration of chlorproma zine before the palatopharyngeal area was irritated by an injection of croton oil. The purpose of this current study is to report an experimental evidence in which cocaine hydrochloride produced shock more frequently if it was given by submucosal injection into the palate of guinea pigs than if given by hypodermic or intravenous injection, and the shock was successfully prevented

STUDY ON SHOCK RESULTING FROM STIMULATION OF THE PALATINE AREA BY COCAINE AND ITS PROPHYLAXIS IN GUINEA PIGS