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It was found by Beeston et al.(1) that fatty liver is induced in the rat by giving a choline-deficient diet supplemented with cystine and the development of this fatty liver is prevented by the administration of choline. Supplementation of the diete with methionine has also been known to have a preventive effect on this fatty liver12>. Although methionine is an essential amino acid and is required for the growth of animals, many reports have been made of a rather inhibitory action of this amino acid upon growth when given in excess(3-6). The growth inhibiting action of methionine is alleviated in the presence of an appropriate amount of glycine or arginine(7,8.9). Giving glycine in excess, however , has been reported to be rather inhibitory on growth (8, 10, 11). According to Hsu et al.("), leucine, glutamic acid and aspartic acid also inhibit growth of the chicken when these amino acids are supplied in excess. It was also indicated in the experiment by Harper et al. (12) that an excess amount of methionine, as referred to above, inhibits growth of animals and causes fatty liver. In view of these data, the present experiment was performed to determine whether the amino acids mentioned above, except for cystine and methionine, also produce fatty livers when they are given in excess, and if they do cause fatty livers, what the effect of supplying other amino acids on this kind of fatty livers is.

FATTY LIVERS INDUCED BY AMINO ACIDS AND INFLUENCE OF OTHER AMINO ACIDS ON THEM