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Two hundred fifty four prostate glands in Japanese over 30 years of age were pathologically studied in unselected autopsy cases.The following results were obtained:1) After a screening of the large number of sections of the glands, 125 foci recognized as the characteristic lesions were histologically analyzed in details by two dimensions, that is, epithelial pattern and stromal invasion. These foci revealed a wide range from a low to a high degree of atypism and were divided into three groups.2) Age incidence, size, number localization and histological patterns of the foci were described respectively on each groups.3) Group 1 included four cases of primary prostatic carcinoma (true latent carcinoma). They were found with an incidence of 2.4 per cent out of 170 cases of men over 50 years of age.4) The foci divided into Group 2 revealed an incidence of 13.5 per cent out of men over 50 years of age. They showed varied degrees of cellular atypism and invasion. Although some of them showed atypism similar to that in Group 1, they were interpreted as a transitional stage to the latent prostatic carcinoma and also might be called “precancer” in microscopical analysis of the present series.5) In group 2 the “elastosis” was recognized in the surrounding tissues of proliferating glands, especially with the close relation to epithelial cells. The significance of the elastosis is briefly discussed with the concept of “tissue induction.”6) Group 3 consisted of glands with senile atrophic changes, atypical pro-liferation in nodular hyperplasia and inflammatory process. There were neither malignant growths nor the possibility of misinterpreting foci.Grateful acknowledgement is made to Prof. Dr. H. Tamura, Director of Depart-ment of Urology, and to Prof. Dr. T. Kobayashi, Department of Pathology. The suggestions and encouragement of Assistant Prof. Dr. H. Watanabe, Department of Pathology, is also grateful acknowledged. My thanks are also to Prof. Dr. K. Kage-yama, department of Pathology, and to Instructor Dr. Tofukuji, Department of Urology.

PATHOLOGICAL STUDIES ON THE PROSTATE GLANDS OF JAPANESE, WITH SPECIAL REFERENCE TO LATENT MALIGNANCY