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Background/Aim: Ulcerative colitis (UC) is a chronic, relapsing inflammatory disease affecting distal colon and rectum with complex pathogenesis and diagnosis, indicating on need for new diagnostic and prognostic markers. The aim of study was to determine fecal values of TNF-α, IL-17, IL-10 and sST2 in patients with UC and the relationship with clinicopathological aspects. Methods: The samples of stool of 80 patients with UC were analyzed. Concentrations of TNF-α, IL-17, IL-10 and sST2 were measured by ELISA. Results: Concentrations of TNF-α, IL-17 and sST2 were significantly increased in feces of patients with higher endoscopic, clinical and total Mayo score, as well as in patients with intense crypt destruction, erosion of the mucous membranes, architectural changes, neutrophil infiltration and eosinophil infiltration. Local value of anti-inflammatory cytokine IL-10 in liquid fraction of feces was increased in patients with advanced endoscopic stage of UC. Moderate positive correlation between fecal sST2/IL-17 and clinical and histological parameters of disease severity and also strong correlation between sST2 and IL-17 was also observed in feces of patients with UC. Analysis of Receiver Operating Characteristic (ROC) curves showed that optimal cut off value for sST2 of 624,0 pg/g allows discrimination of clinical stages of UC. Conclusion: Increased fecal value of sST2 in UC patients with higher endoscopic, clinical and histological stage of disease may be considered as a sign of the disease severity. The fecal values of sST2 can be used as a valuable marker for UC severity.

Fecal sST2 correlates with the disease severity of ulcerative colitis