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Background/Aim. Currently used radiopharmaceuticals are nonspecific and most   of them are accumulated by benign tumors as well as inflammatory lesions,   abscess or granulomatous lesions. Some factors such as the choice of   radiopharmaceutical applied, histopathologic type of tumor, its size,   location or previous tumor treatment could influence tumor imaging   sensitivity. The aim of this study was to investigate accumulation of   99mTc-methoxy-2-isobutylisonitrile (99mTc- MIBI) by counting early/delayed   uptake and release of this radiopharmaceutical inside lung tumors and   evaluating possible factors which could be involved in its accumulation.   Methods. Two-phase 99mTc-methoxy-2-isobutylisonitrile single photon emission   computed tomography scan (early and delayed scan) was performed in 60   patients with lung tumors (the group 1 - 30 benign, and the group 2 - 30   malignant tumors). We calculated the uptake ratio on early (early ratio -   ER), delayed images (delayed ratio - DR) and retention index (RI). Individual   influence of etiology, diameter, localization, and histological type on   uptake/release values was evaluated with regression analysis. Results. The   values of ER and DR were significantly different in both groups (p < 0.01),   showing lower values in benign vs malignant lung tumors (ER 1.36 ± 0.094 and   DR 1.25 ± 0.089 vs ER = 1.93 ± 0.106 and DR = 1.7 ± 0.095 respectively).   Tumor size showed a significant influence on the change of ER and DR values   (p < 0.01), with greater uptake in tumors > 3 cm. RI values showed no   significance between the two groups (p > 0.05). Conclusion. The uptake ratio   of 99mTc-methoxy-2-isobutylisonitrile could be a useful index in   differentiating lung tumors, while RI has no influence on this. Among the   evaluated factors, ER and DR values are significantly influenced only by the   diameter of lung tumor, while localization or different histological types   between the groups has no influence on this

Lung tumors: Early and delayed ratio of 99mTc-methoxy-2-isobutylisonitrile accumulation