English (United Kingdom)

https://curated-unify.zendy.io/wp-json/zendy-region/v1/featured_content/oa?rat=en

https://curated-unify.zendy.io/wp-json/zendy-region/v1/highlighted_journal/

Global: Zendy Plus annual

Presents the access of premium content as premium feature

Premium Content

Presents the keyphrase highlighting as premium feature

Keyphrase Highlighting

Presents the summarisation as premium feature

Summarisation

Insights

Presents the pdf analysis as premium feature

PDF Analysis

Presents the zaia usage as premium feature

ZAIA

Global: Zendy Tools annual

Global: Zendy Free Plan

Global: Zendy Tools monthly

Global: Zendy Plus monthly

By applying of aconitic test in in vivo experiments in rats under deep   anesthesia, there was investigated the antiarrhythmic potential of newly   synthetized fluorinated derivatives of propafenone. The animals were divided   into four experimental groups. The first (aconitine group) was treated with   aconitine at a dose of 60μg/kg, which led to pronounced cardiac rhythm   disorder in a short period of time. The appearance of ventricular   extrasystole (VES) was taken as a parameter for ascertainment of cardiac   rhytm disorder. The remaining three animal groups were taken for testing the   potential of propafenone and propafenone fluorinated derivatives to stop the   arrhythmia, and which was induced by i.v. aconitine injection (60|jg/kg).   Propafenone, as well as 5OF derivative, did not convert the disturbed cardiac   rhythm (survival of animals was 0%). By applying 5PF derivative in a dose of   6 mg/kg, the animals survived with occasional establishment of sinus rhythm.   [Projekat Ministarstva nauke Republike Srbije, br. TR 31020 i br. OI 172041

Testing of newly synthesized propafenone derivatives antiarrhythmic activity in aconitic model of cardiac arrhythmia in rats