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Cadmium (Cd) is today one of the most significant metal poisons, both in the  area of professional as well as of eco toxicology. In the organism, cadmium  has a harmful effect on the kidneys, liver, bones, testicles, etc., and,  based on evidence in humans that it causes lung carcinoma, it has been placed  in the first group of carcinogens. In spite of numerous data in literature on  the harmful effects of cadmium, the interactions between cadmium and  bioelements as a significant mechanism for cadmium toxicity have still not  been sufficiently explained. Since the data so far point to a positive effect  of supplementation with certain bioelements regarding toxicity and cadmium  content in the organism, the objective of this work was to investigate the  effect of increased simultaneous intake of magnesium, zinc and copper on  urinary elimination of cadmium in rabbits exposed to cadmium. Rabbits were  divided into two groups: Cd group - for a period of 28 days the animals  received per os 10 mg Cd/kg b.m/day and Cd+(Mg+Zn+Cu) group - 10 mg Cd/kg  b.m. + 40 mg Mg/kg b.m, 20 mg Zn/kg b.m. and 10 mg Cu/kg b.m/day. Daily urine  was collected on days 0, 10, 15, 17, 19, 21, 23, 25, and 28 of the  experiment. Following decomposition of urine samples with the help of  concentrated HNO3 and HClO4 (4:1), the metal concentration was determined  using the method of atomic absorption spectrophotometry. Supplementation with  magnesium, zinc and copper did not result in significant changes in the  elimination of cadmium through urine in animals poisoned with cadmium, in  comparison with the animals that were administered only cadmium, while the  concentration of all three applied bioelements in urine was significantly  increased. It can be concluded that the simultaneous administration of  increased doses of zinc, copper and magnesium does not have a positive effect  on the elimination of cadmium in conditions when rabbits are poisoned with  cadmium

Investigations of effects of magnesium, zinc and copper on cadmium excretion in rabbits