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Etiology of abnormalities in tooth structure has been subject of numerous  studies but still has not been fully understood. Heredity is an established  etiological factor for many types of structural anomalies of the teeth.  Factors that cause changes in enamel structure may be genetic, immunologic  and teratogenic or systemic diseases. Genetic changes may include individual  genes, micro deletions or chromosomal defects. Systemic diseases can be  associated with anomalies of tooth structure and diversity of clinical  picture requires a multidisciplinary approach to the therapy. Amelogenesis  imperfecta (AI) represents a large group of structural abnormalities of the  teeth. AI can exist independently or as a part of large number of syndromes  and systemic diseases. Knowledge of clinical presentation, etiology,  pathogenesis of structural anomalies of the teeth and their association with  certain systemic diseases is of great importance to everyday dental practice  in terms of prevention, prognosis and therapy. Also, it is necessary to  expand basic knowledge of pediatricians in regards to the clinical picture of  anomalies in tooth structure and their possible association with a wide range  of systemic diseases and syndromes, in order to provide comprehensive  clinical treatment. Therefore, the aim of this study was to present  etiopathogenesis and classification and to describe the most important  abnormalities of enamel structure and their association with systemic  diseases and syndromes

Abnormalities in enamel structure and their association with systemic diseases and syndromes