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. Direct pulp capping procedure is a therapeutic application of a   drug on exposed tooth pulp in order to ensure the closure of the pulp   chamber and to allow the healing process to take place. Objective. The aim   of this study was to examine the histological effects of Emdogain® on   exposed tooth pulp of a Vietnamese pig (Sus scrofa verus). Methods. The   study comprised 20 teeth of a Vietnamese pig. After class V preparation on   the buccal surfaces of incisors, canines and first premolars, pulp was   exposed. In the experimental group, the perforations were capped with   Emdogain® (Straumann, Basel, Switzerland), while in the control group pulp   capping was performed with MTA® (Dentsply Tulsa Dental, Johnson City, TN,   USA). All cavities were restored with glass-ionomer cement (GC Fuji VIII, GC   Corporation, Tokyo, Japan). The observational period was 28 days, after   which the animal was sacrificed and histological preparations were made. A   light microscope was used to analyze dentin bridge formation, tissue   reorganization and inflammation, and the presence of bacteria in the pulp.   Results. The formation of dentin bridge was observed in the experimental and   control groups. Inflammation of the pulp was mild to moderate in both   groups. Angiogenesis and many odontoblast-like cells, responsible for dentin   bridge formation, were observed. Necrosis was not observed in any case, nor   were bacteria present in the pulp. Conclusion. Histological analysis   indicated a favorable therapeutic effect of Emdogain® Gel in direct pulp   capping of Vietnamese pigs. Pulp reaction was similar to that of MTA®.   [Projekat Ministarstva nauke Republike Srbije, br. ON172026

Histological effects of enamel matrix derivative on exposed dental pulp