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. Hemostatic abnormalities in liver cirrhosis are complex and  multifactorial and may predispose to prolonged hemorrhage following invasive  procedures. Due to increased perioperative bleeding risks, patients with  cirrhosis should undergo elective surgery after making medical preparations.  It has been shown that 1-deamino-8-D-arginine vasopressin (DDAVP),  desmopressin, can be used as a safe and effective remedy in preventing and  treating bleeding in cirrhotics. However, there is still scarce information  of adequate test(s) for assessing effects of DDAVP in platelet dysfunction.  The use of platelet function analyzer-100 (PFA-100) allows more reliable  assessment of impaired primary hemostasis as well as follow-up of hemostatic  changes induced by DDAVP effects. Case Outline. In a 49-year-old male with  ethylic liver cirrhosis and prolonged bleeding time scheduled for elective  left side inguinal hernia repair, we carried out PFA-100 testing to  investigate the patient’s platelet functional status. Results were  affirmative for the presence of platelet functional problems. By standard  coagulation tests the patient was also identified as having secondary  hemostasis. Preoperatively, PFA-100 was used to test the patient’s response  to a standard dose of DDAVP, which was favorable. The patient was operated  after medical preparations with DDAVP and vitamin K. Neither bleeding  complications nor side effects of DDAVP were recorded in the perioperative  period. Conclusion. The PFA-100 is a simple and reliable test for the  assessment of primary hemostasis as well as in monitoring of DDAVP therapy

PFA-100 test in the detection of platelet dysfunction and monitoring DDAVP in a patient with liver cirrhosis undergoing inguinal hernia repair