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. Lung cancer is the leading cause of death from malignancy in  Serbia. Objective. This is a retrospective analysis of lung cancer  epidemiological changes regarding to its histological type and patients’ age  of both genders. Data were based on surgically treated lung cancer patients  from 1985 to 2005. Methods. Data were collected from 972 pathohistological  reports of operated patients of both genders divided into age groups.  Histological types of lung cancer were distributed in four major groups:  squamous cell cancer (SCC), adenocarcinoma (AC), small cell cancer (SCLC) and  other rare histological types. Both genders together and separately were  analysed. Chi-square with the level of significance p<0.05 and chi-square  test for trends were used as statistical methods. Results. SCC predominated  in both genders; in 44.7% females and 68.0% males. AC was less frequently  diagnosed (21.8%) than SCC (64.0%) in both genders and all age groups. The  most frequently operated patients were aged between 51 and 60 years (36.6%)  with SCC and AC predominance. Three patients with SCLC were operated in 61-70  age-group. In age-group up to 30 years, three (0.5%) patients were operated  on for SCC and other rare lung tumours, respectively. Predominance of other  rare lung tumours was established in 51-60 age-group, 25% of patients of both  genders. Conclusion. SCC is the most frequent histological type of lung  cancer found in all age groups and in both genders of surgically treated  patients

Histological types and age distribution of lung cancer operated patients over a 20-year period: A pathohistological based study