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. The importance of understanding the biology of breast cancer is increasing and the determination of certain phenotypic characteristics of malignant cells, especially estrogen, progesterone and human epidermal growth factor receptor 2 expression, became a standard evaluation procedure in breast cancer patients, in order to provide prognostic information and best therapeutic options. Material and methods. This study included a total of 206 patients, all treated and followed up in the Daily Chemotherapy Hospital of the Health Center Vranje. Estrogen, progesterone and human epidermal growth factor receptor 2 statuses were evaluated in all patients to assess their potential impact on the progression-free and overall survival. Results. Two-thirds of patients were diagnosed at the early stage of the disease. Ductal carcinoma was the most common histological type. Patients with early stage breast cancer, with hormone-receptor positive and human epidermal growth factor receptor 2 negative tumors, had a significantly longer progression-free survival. Conclusion. Hormone-receptor and human epidermal growth factor receptor 2 status evaluation is still of great clinical importance with a reliable prognostic value in breast cancer patients.

Prognostic significance of estrogen receptor, progesterone receptor and human epidermal growth factor receptor 2 in patients with breast cancer