Open AccessDesign, synthesis and biological evaluation of new substituted benzofuran-based derivatives via C−H bond activation
Author(s) -
Behjat Pouramiri,
Mahboobeh Zahedifar,
Adileh Ayati,
Farah Pouramiri,
Mahdiyeh Ahmadi
Publication year - 2020
Publication title -
journal of the serbian chemical society
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 0.227
H-Index - 45
eISSN - 1820-7421
pISSN - 0352-5139
DOI - 10.2298/jsc191231039p
Subject(s) - benzofuran , acetylcholinesterase , chemistry , aché , combinatorial chemistry , in vitro , stereochemistry , enzyme , organic chemistry , biochemistry
A series of biologically active disubstituted benzofuran derivatives ( 3a – d ) have been designed and synthesized via C–H bond activation reaction. The chemical structures of all final compounds were confirmed by spectroscopic methods. In vitro anti acetylcholinesterase (AChE) activities of these novel compounds were evaluated and showed low to moderate results. Among them, compound 3d moderately inhibited AChE activities with 68.12 % value.
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