English (United Kingdom)

https://curated-unify.zendy.io/wp-json/zendy-region/v1/featured_content/oa?rat=en

https://curated-unify.zendy.io/wp-json/zendy-region/v1/highlighted_journal/

Global: Zendy Plus annual

Presents the access of premium content as premium feature

Premium Content

Presents the keyphrase highlighting as premium feature

Keyphrase Highlighting

Presents the summarisation as premium feature

Summarisation

Insights

Presents the pdf analysis as premium feature

PDF Analysis

Presents the zaia usage as premium feature

ZAIA

Global: Zendy Tools annual

Global: Zendy Free Plan

Global: Zendy Tools monthly

Global: Zendy Plus monthly

Base-catalysed heterocyclization of either N -aryl- N' -[imino(nitro­amino)methyl]thioureas or N -aryl- N' -cyanothioureas by reaction with 2-bromo-1-(2,6-di- t -butyl-4-hydroxyphenyl)ethanone afforded 4-amino-2-(arylamino)-5-(3,5-di- t -butyl-4-hydroxybenzoyl)thiazoles, designed as molecular hybrids of hindered phenolic and 2-aminothiazole moieties. These compounds were screened for their inhi­bition activity on carbohydrate hydrolyzing enzymes. Thus, [4-amino-2-(phenylamino)-5-thiazolyl](3,5-di- t -butyl-4-hydroxyphenyl)­methanone exhibited α -glucosidase inhibition activity with an IC 50 value of 117 µM while the standard com­pound acarbose showed an IC 50 value of 48.3 µM and {4-amino-2-[(4-methylphenyl)amino]-5-thiazolyl}(3,5-di- t -butyl-4-hydroxyphenyl)methanone showed good α -amylase inhibition activity with an IC 50 value of 283 µM compared to acarbose ( IC 50 532 µM). The antioxidant activities of the hindered phenolic thiazoles were also investigated and the 2-[(4-methoxyphenyl)amino] derivative showed an antioxidant activity better than that of butylated hydroxyanisole in the 2,2-diphenyl-1-picryl­hyd­razyl rad­ical scavenging assay, better than that of either vitamin C or curcumin in the ferric ion-reducing antioxidant potential assay and comparable with that of but­yl­ated hydroxyanisole in the β -carotene bleaching assay.

Hindered phenolic aminothiazoles - synthesis, α-glucosidase, α-amylase inhibitory and antioxidant activities