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Experimental molar solubilities of clonazepam and diazepam in binary and   ternary mixtures of polyethylene glycols (PEGs) 400 or 600, propylene glycol   (PG) and water (138 data points) along with the density of the saturated   solutions at 298.2K were reported. The Jouyban-Acree model was used to fit   to the measurements for providing a computational method. Employing the   solubilities in the mono-solvents, the measured solubilities in mixed   solvents were back-calculated and the overall mean percentage deviations   (OMPDs) of the model were 16.0 % and 19.2% for diazepam and clonazepam,   respectively. Addition of the Hansen solubility parameters to the model helps   us to train all the data sets (clonazepam and diazepam) at once and the   back-calculated OMPD for this analysis was 19.3%

journal of the serbian chemical society

Solubility of clonazepam and diazepam in binary and ternary mixtures of polyethylene glycols 400 or 600, propylene glycol and water at 298.2K - experimental data and modeling