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An efficient methodology for the synthesis of novel substituted  pyrido[3,2,1-jk]carbazole via Friedel-Crafts cyclialkylations is reported.  The methodology was realized by three-step protocol involved the addition of  carbazole to 3-methylcrotononitrile. The resulted nitrile was hydrolyzed to  desired ester, followed by addition of Grignard reagents to afford tertiary  alcohols and/or reacted directly with different Grignard reagent to form the  desired ketones. The later ketones were converted to both secondary and  tertiary alcohols by reduction with LAH and addition of Grignard reagents  respectively. These carbinols were cyclialkylated under Friedel-Crafts  conditions catalyzed by AlCl3/CH3NO2, PTSA and PPA to give tri-and  tetrasubstituted pyrido[3,2,1-jk]carbazole

Modern Friedel-Crafts chemistry: Part 36. Facile synthesis of some new pyrido[3,2,1-jk]carbazoles via Friedel-Crafts cyclialkylations