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The clean cyclization of chalcones (1a-c/2a-c) with hydrazine hydrate tinder microwave irradiation afforded pyrazolines derivatised with sydnone (3d-i/4d-i), which underwent 1,3-dipolar cyclo-addition with acetic anhydride to form pyrazolines appended with 1,3,4-oxadiazoles (5g-1/6g-1). The newly synthesized compounds were confirmed by spectral and elemental analyses. In comparison to classical heating, the results indicate that microwave irradiation affords higher yields,, shorter reaction times (4-12 min) and cleaner reactions

Expeditious synthesis of 1,3,4-oxadiazole derivatives via sydnones