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Poor solubility is one of the key reasons for the poor bioavailability of   these drugs. This paper displays a formulation of a solid surfactant system   with carbamazepine, in order to increase its dissolution rate. Solid state   surfactant systems are formed by application of fractal experimental design.   Poloxamer 237 and Poloxamer 338 were used as surfactants and Brij® 35 was   used as the co-surfactant. The ratios of the excipients and carbamazepine   were varied and their effects on the dissolution rate of carbamazepine were   examined. Moreover, the effects of the addition of natural (diatomite) and a   synthetic adsorbent carrier (Neusiline UFL2) on the dissolution rate of   carbamazepine were also tested. The prepared surfactant systems were   characterized and the influence of the excipients on possible changes of the   polymorphous form of carbamazepine examined by application of analytical   techniques (DSC, TGA, FT-IR, PXRD). It was determined that an appropriate   selection of the excipient type and ratio could provide a significant   increase in the carbamazepine dissolution rate. By application of analytical   techniques, it was found that that the employed excipients induce a   transition of carbamazepine into the amorphous form and that the selected   sample was stable for three months, when kept under ambient conditions.   [Projekat Ministarstva nauke Republike Srbije, br. TR34007

journal of the serbian chemical society

Application of experimental design in examination of the dissolution rate of carbamazepine from formulations: Characterization of the optimal formulation by DSC, TGA, FT-IR and PXRD analysis