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Antimicrobial activity of Usnea barbata especially against bacteria involved   in pathogenesis of various skin conditions has been well documented in   literature. Nevertheless, there are no papers dealing with formulation of its   isolates into topical preparations for treatment of skin infections. In   present study, alkyl polyglucoside (APG) - based vehicle was developed as   carrier of U. barbata CO2-supercritical extract (U-SE) that demonstrated the   best antimicrobial potential in preliminary screening. For comparison, chosen   extract in the same concentration and using the same procedure was   incorporated into a pharmacopoeial vehicle. Comparative evaluation of   physicochemical stability, efficiency and safety proved APG-based vehicle to   possess certain preferential features as carrier of U-SE compared to the   reference one, composing a topical formulation with potential clinical   relevance in treatment of skin infections. [Projekat Ministarstva nauke   Republike Srbije, br. III45017 i br. TR34031

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Alkyl polyglucoside-stabilized emulsion as a prospective vehicle for Usnea barbata CO2-supercritical extract: Assessing stability, safety and efficiency of a topical formulation